Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Dec 13;11:23890. doi: 10.1038/s41598-021-03285-w

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

CircFOXM1 promotes proliferative and metastatic abilities of HCC. (A) The circFOXM1 knockdown efficacy after transfection of circFOXM1 siRNA in Huh7 and HepG2 cells, as well as the circFOXM1 overexpression efficacy after transfection of pLCDH-circFOXM1 in HCCLM3 and MHCC97-H cells. (B) Viabilities determined by CCK-8 assay in Huh7 and HepG2 HCC cells transfected with NC or circFOXM1 siRNA, and in HCCLM3 and MHCC97-H HCC cells transfected with NC or pLCDH-circFOXM1. (C) Migration ability determined by transwell assay in Huh7 and HepG2 HCC cells transfected with NC or circFOXM1 siRNA. (D) Invasion ability determined by transwell assay in Huh7 and HepG2 HCC cells transfected with NC or circFOXM1 siRNA. (E) Migration ability determined by transwell assay in HCCLM3 and MHCC97-H HCC cells transfected with NC or pLCDH-circFOXM1. (F) Invasion ability determined by transwell assay in HCCLM3 and MHCC97-H cells transfected with NC or pLCDH-circFOXM1. CircFOXM1 silencing inhibits HCC xenograft growth in vivo (n = 5). (G) Tumor volume, (H) Tumor weight. *p < 0.05; **p < 0.01, ***p < 0.001.