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. 2021 Dec 13;11:23890. doi: 10.1038/s41598-021-03285-w

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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CircFOXM1 promotes viability, migration and invasion abilities of HCC cells via sponging miR-1179 to increase SPAG5 expression. (A) Viabilities of Huh7 and HepG2 cells after circFOXM1 silencing with/without miR-1179 inhibitor or SPAG5 overexpression determined by CCK-8 assay. (B) Viabilities of HCCLM3 and MHCC97-H cells after circFOXM1 overexpression with/without miR-1179 mimics or SPAG5 silencing determined by CCK-8 assay. (C) Migration capabilities of Huh7 and HepG2 cells after circFOXM1 silencing with/without miR-1179 inhibitor or SPAG5 overexpression determined by transwell assay without Matrigel. (D) Invasion capabilities of Huh7 and HepG2 cells after circFOXM1 silencing with/without miR-1179 inhibitor or SPAG5 overexpression determined by transwell assay with Matrigel. (E) Migration capabilities of HCCLM3 and MHCC97-H cells after circFOXM1 overexpression with/without miR-1179 mimics or SPAG5 silencing determined by transwell assay without Matrigel. (F) Invasion capabilities of HCCLM3 and MHCC97-H cells after circFOXM1 overexpression with/without miR-1179 mimics or SPAG5 silencing determined by transwell assay with Matrigel. *p < 0.05; **p < 0.01, ***p < 0.001.