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. 2021 Dec 13;7:114. doi: 10.1038/s41531-021-00259-7

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a Schematic of the viral injections (upper) and the GFP-labeling patterns in the OB of animals injected with AAV-CMV-hm-syn-ires-GFP (hα-syn) or AAV-CMV-GFP (control) (lower). b The expression of total α-syn and pSer129-α-syn in OB tissue 3 weeks after viral injection, measured with western blots. n = 4 mice for each group. All blots derive from the same experiment and that they were processed in parallel. c Representative images showing GFP-positive, pSer129-α-syn-positive, and co-labeled cells in different layers of the OB 3 weeks after viral injection. The white arrows indicate α-syn aggregates. Scale bars = 100 μm. d Quantitative analysis of the density of pSer129-α-syn-positive signals in different layers of OB. n = 12 slices from 4 mice for each group. GCL granule cell layer, MCL mitral cell layer, EPL external plexiform layer, GL glomerular layer, α-syn α-synuclein; **p < 0.01; ***p < 0.001. Data are presented as mean ± SEM.