Skip to main content
. 2021 Dec 13;7:114. doi: 10.1038/s41531-021-00259-7

Fig. 7. α-Synuclein aggregates impair the odor-evoked calcium responses of granule cells in vivo.

Fig. 7

a Schematic for fiber photometry recording of calcium signals from granule cells expressing jRGECD1a in control or hα-syn mice. b Expression of jRGECD1a in the granule cell layer of the OB from a representative control mouse. Scale bars = 20 μm. c, d Trial-to-trial pseudo-colored heat maps (top) and trial-averaged traces (bottom; mean ± SEM) of the calcium responses evoked by passive exposure to two different odors, recorded from control (c) and hα-syn (d) mice. e Heat map illustrating the calcium responses for all animal–odor pairs recorded from control and hα-syn mice. f The averaged calcium response (ΔF/F, %) of granule cells during odor delivery (n = 64 and n = 72 animal–odor pairs; control and hα-syn groups, respectively). **p < 0.01. Data are presented as mean ± SEM.