Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Dec 13;11:23841. doi: 10.1038/s41598-021-03216-9

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Effect of MIA by poly I:C or resiquimod on microglial markers in foetal brain. Foetal brain tissues were collected after 4 h MIA (PBS, poly I:C (20 mg/kg, LMW), resiquimod (2 mg/kg)). (A,B) Aif1 was increased by resiquimod, however, Cx3cr1 was downregulated by resiquimod compared to PBS. Both genes were not changed by poly I:C. (C) Tmem119 was significantly downregulated by MIA compared to PBS. (D, E) Ccr2 was significantly downregulated by MIA compared to PBS, on the other hand, Ly6c2 was not changed by MIA. Absolute quantification was performed via RT-qPCR and the data were normalised to Gapdh and Tbp. The individual dots are shown along with mean ± SEM. Colour indicates dams within a single treatment (same colour means “same dam”). The data were log transformed and analysed by two way-ANOVA, Tukey post-hoc test (n = 14–18 independent samples; *p ≤ 0.05, **p ≤ 0.005, ***p ≤ 0.001, ****p ≤ 0.0001). Details of ANOVA F values and p values are provided in Supplementary Table 1.