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. 2021 Dec 13;6:151. doi: 10.1038/s41541-021-00414-4

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© This is a U.S. government work and not under copyright protection in the U.S.; foreign copyright protection may apply 2021

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Fig. 2 — a Magnitude of the T cell response in the dLNs at day 7 post-priming vaccination (n = 5 mice/group/time point). b Percentage of IL-2 expressing (left panel) and TNF-α expressing (right panel) SARS-CoV-2 spike-specific CD4⁺ T cells in the dLNs 10 days post-vaccination, following stimulation with spike S1 peptide pool. Bars indicate mean + s.d. c IL-2 and TNF-α are co-expressed in the SARS-CoV-2 spike-specific CD4⁺ T cells, indicating mainly a T_H 1 type response. d Cytokine profile in the sera of vaccinated mice as determined by multiplex ECLIA using Meso Scale Discovery (MSD) platform on days 3, 5, and 10 post-vaccination. Dots represent data from individual mice, horizontal lines represent mean, and error bars represent s.d. Experiments were repeated twice and differences between the two groups were analyzed by using a nonparametric Mann–Whitney U-test with p ≤ 0.05 considered as statistically significant.