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. 2021 Dec 13;6:151. doi: 10.1038/s41541-021-00414-4

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© This is a U.S. government work and not under copyright protection in the U.S.; foreign copyright protection may apply 2021

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Fig. 4 — a, b Percentage of SARS-CoV-2 spike-specific T cells in the mediastinal lymph nodes at week 6 (3 weeks post-prime-boost vaccination). a Percentage of CD4⁺ and CD8⁺ T cells expressing IFN-γ, TNF-α, IL-17A, and b CD4⁺ T cells expressing IL-10. Each sample is representative of the pooled lymph nodes within the vaccine group. c SARS-CoV-2 spike-specific CD4⁺ and CD8⁺ T cells in the mediastinal lymph nodes following prime-boost vaccination with SpFN + ALFQ co-express IFN-γ and TNF-α upon peptide stimulation. d Splenocytes were stimulated with SARS-CoV-2 spike-specific peptides and cytokines in the culture supernatants were measured by the ECLIA-based multiplex MSD platform. Dots represent data from individual mice (n = 5/group), horizontal lines represent mean and error bars represent s.d. Differences between the two groups were analyzed by using a nonparametric Mann–Whitney U-test with p ≤ 0.05 considered as statistically significant.