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. 2021 Dec 13;11:23895. doi: 10.1038/s41598-021-03265-0

Table 5.

Comparison of CAD software ROC AUC by key demographic and clinical factors.

	Qure.ai		Delft Imaging		DeepTek
	ROC AUC (95% CI)	P-value^╪	ROC AUC (95% CI)	P-value^╪	ROC AUC (95% CI)	P-value^╪
	0.82 (0.79–0.85)	–	0.82 (0.78–0.85)	–	0.78 (0.74–0.82)	–
Gender
Male	0.80 (0.76–0.85)	0.222	0.80 (0.76–0.85)	0.363	0.75 (0.71–0.80)	0.066
Female	0.85 (0.79–0.92)	0.222	0.84 (0.78–0.90)	0.363	0.83 (0.76–0.90)	0.066
Age group
15–54 years	0.84 (0.79–0.90)	0.248	0.86 (0.81–0.91)	0.048	0.79 (0.73–0.85)	0.534
≥ 55 years	0.80 (0.76–0.85)	0.248	0.79 (0.74–0.84)	0.048	0.77 (0.72–0.82)	0.534
C + F + WL + NS
No	0.78 (0.71–0.86)	0.294	0.78 (0.72–0.85)	0.307	0.75 (0.67–0.83)	0.489
Yes	0.83 (0.79–0.87)	0.294	0.82 (0.78–0.86)	0.307	0.78 (0.74–0.82)	0.489
History of TB
No	0.86 (0.83–0.90)	0.002	0.85 (0.82–0.89)	0.019	0.83 (0.79–0.87)	0.001
Yes	0.73 (0.65–0.80)	0.002	0.76 (0.69–0.83)	0.019	0.69 (0.62–0.77)	0.001
Radiography system
JPI Healthcare	0.85 (0.79–0.90)	0.072	0.82 (0.76–0.87)	0.514	0.81 (0.75–0.86)	0.027
DRTECH	0.78 (0.73–0.83)	0.072	0.79 (0.75–0.84)	0.514	0.72 (0.67–0.77)	0.027

	Lunit		JF Healthcare		InferVision		OXIPIT
	ROC AUC (95% CI)	P-value^╪	ROC AUC (95% CI)	P-value^╪	ROC AUC (95% CI)	P-Value^╪	ROC AUC (95% CI)	P-value^╪
	0.82 (0.79–0.86)	–	0.77 (0.73–0.81)	–	0.76 (0.72–0.80)	–	0.73 (0.69–0.77)	–
Gender
Male	0.81 (0.77–0.86)	0.373	0.74 (0.69–0.79)	0.057	0.75 (0.70–0.79)	0.712	0.70 (0.66–0.75)	0.718
Female	0.85 (0.79–0.90)	0.373	0.82 (0.75–0.90)	0.057	0.77 (0.68–0.86)	0.712	0.77 (0.69–0.84)	0.718
Age group
15–54 years	0.83 (0.77–0.89)	0.771	0.82 (0.76–0.87)	0.044	0.79 (0.73–0.85)	0.127	0.75 (0.69–0.81)	0.335
≥ 55 years	0.82 (0.77–0.86)	0.771	0.74 (0.69–0.79)	0.044	0.73 (0.67–0.78)	0.127	0.71 (0.66–0.76)	0.335
C + F + WL + NS
No	0.79 (0.72–0.85)	0.244	0.71 (0.63–0.80)	0.142	0.73 (0.64–0.82)	0.525	0.72 (0.64–0.80)	0.911
Yes	0.83 (0.79–0.88)	0.244	0.78 (0.74–0.83)	0.142	0.76 (0.72–0.81)	0.525	0.72 (0.68–0.77)	0.911
History of TB
No	0.86 (0.82–0.90)	0.019	0.82 (0.77–0.86)	0.001	0.78 (0.73–0.83)	0.122	0.79 (0.74–0.83)	< 0.001
Yes	0.75 (0.68–0.83)	0.019	0.66 (0.59–0.74)	0.001	0.71 (0.64–0.78)	0.122	0.63 (0.55–0.70)	< 0.001
Radiography system
JPI Healthcare	0.79 (0.71–0.86)	0.790	0.76 (0.69–0.83)	0.791	0.78 (0.70–0.86)	0.118	0.77 (0.71–0.84)	0.006
DRTECH	0.80 (0.75–0.84)	0.790	0.75 (0.70–0.80)	0.791	0.70 (0.65–0.75)	0.118	0.65 (0.60–0.71)	0.006

ROC AUC area under the receiver operating characteristic curve.

Significant values are in bold.

^╪Chi-squared test.