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. 2021 Dec 13;11:23913. doi: 10.1038/s41598-021-03270-3

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fluorescent confocal microscopy images of rabbit keratectomy cornea without treatment and with polyethylene glycol (PEG)-collagen hydrogel application. (A) Cy5 stained with PEG-collagen hydrogel (magenta) was maintained underneath a multilayered, migrated epithelial layer stained with CK3 (green) after 1 week of keratectomy. (B) Immunohistochemical staining of α-smooth muscle actin (α-SMA), vimentin, and desmin markers for myofibroblasts in the keratectomy-subjected rabbit cornea over 1 week and 4 weeks. Note the high density of α-SMA (red) and vimentin (green) in the anterior stroma of rabbit corneas at 1 week after keratectomy alone. After 4 weeks, α-SMA (red) expression remained in the epithelium in the keratectomy-only group, whereas low α-SMA expression was found in the keratectomy with PEG-collagen hydrogel-treated group. Desmin (red) was expressed in the epithelium of the keratectomy with PEG-collagen hydrogel-treated group after 1 to 4 weeks.