Table 5.
Receiver operating characteristic (ROC) analysis of redox biomarkers in erythrocytes/plasma of patients with Alzheimer’s disease and the control group.
| Biomarker | Erythrocytes/Plasma | |||||||
|---|---|---|---|---|---|---|---|---|
| AUC | 95%Cl | P-value | Cut off | Sensitivity% | 95%Cl | Specificity% | 95%Cl | |
| Antioxidant barrier | ||||||||
| SOD (mU/mg protein) | 0.684 | 0.5458 to 0.8222 | 0.0097 | < 0.5543 | 60.00 | 40.74 to 76.60% | 62.00 | 48.15 to 74.14% |
| CAT (nmol H2O2/min/mg protein) | 0.69 | 0.5164 to 0.8636 | 0.0226 | > 0.1822 | 68.00 | 48.41 to 82.79% | 66.67 | 46.71 to 82.03% |
| GPx (mU/mg protein) | 0.9167 | 0.8235 to 1.000 | < 0.0001 | < 0.1211 | 87.50 | 69.00 to 95.66% | 88.00 | 70.04 to 95.83% |
| UA (μg/mg protein) | 0.8617 | 0.7396 to 0.9837 | < 0.0001 | > 33.37 | 87.50 | 69.00 to 95.66% | 88.00 | 70.04 to 95.83% |
| GSH (ng/mg protein) | 0.8455 | 0.7330 to 0.9579 | < 0.0001 | < 2.293 | 77.27 | 56.56 to 89.88% | 76.00 | 56.57 to 88.50% |
| Redox status | ||||||||
| TAC (μmol/mg protein) | 0.855 | 0.7232 to 0.9868 | < 0.0001 | < 6.199 | 83.33 | 64.15 to 93.32% | 84.00 | 65.35 to 93.60% |
| TOS (nmol/mg protein) | 0.9927 | 0.9761 to 1.000 | < 0.0001 | > 363.1 | 95.45 | 78.20 to 99.77% | 96.00 | 80.46 to 99.79% |
| OSI (TOS/TAC ratio) | 0.9467 | 0.8731 to 1.000 | < 0.0001 | > 60.51 | 90.48 | 71.09 to 98.31% | 92.00 | 75.03 to 98.58% |
| Oxidative and nitrosative stress | ||||||||
| AGE (AFU/mg protein) | 0.9048 | 0.7792 to 1.000 | < 0.0001 | > 1.311 | 90.48 | 71.09 to 98.31% | 92.00 | 75.03 to 98.58% |
| AOPP (nmol/mg protein) | 0.9309 | 0.8598 to 1.000 | < 0.0001 | > 7.789 | 86.36 | 66.67 to 95.25% | 84.00 | 65.35 to 93.60% |
| MDA (μg/mg protein) | 0.7909 | 0.6631 to 0.9187 | 0.0006 | > 393.4 | 68.18 | 47.32 to 83.64% | 68.00 | 48.41 to 82.79% |
| NO (ng/mg protein) | ||||||||
| Peroxynitrite (nmol/mg protein) | 0.6845 | 0.5210 to 0.8480 | 0.0344 | > 224.4 | 57.14 | 36.55 to 75.53% | 58.33 | 38.83 to 75.53% |
| Nitrotyrosine (pmol/mg protein) | 0.8419 | 0.6929 to 0.9909 | < 0.0001 | > 3357 | 80.95 | 60.00 to 92.33% | 80.00 | 60.87 to 91.14% |
| Others | ||||||||
| Aβ (AFU/mg protein) | 0.5543 | 0.3840 to 0.7245 | 0.5297 | > 70,825 | 61.90 | 40.88 to 79.25% | 60.00 | 40.74 to 76.60% |
| IL-1β (ng/mg protein) | 0.9456 | 0.8839 to 1.000 | < 0.0001 | > 34.07 | 84.00 | 65.35 to 93.60% | 84.00 | 65.35 to 93.60% |
AUC—area under curve; SOD—superoxide dismutase; CAT—catalase; GPx—glutathione peroxidase; UA—uric acid; GSH—glutathione; TAC—mean total antioxidant capacity; TOS—mean total oxidant status; OSI—oxidative stress index; AGE—advanced glycation end products; AOPP—advanced oxidation protein products; MDA—malondialdehyde; NO—nitric oxide, Aβ—amyloid beta; IL-1β—Interleukin 1 Beta.