Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Binding affinity of I-Tyr and Tyr as a function of side chain substitution (25 °C)a
| TnIYD |
Kd (μM) |
|
|---|---|---|
| I-Tyr | Tyr | |
| wt | 0.05 ± 0.02 | 0.45 ± 0.07 |
| Y112A | 0.03 ± 0.02 | 0.9 ± 0.1 |
| M41A | 0.25 ± 0.06 | 1.6 ± 0.2 |
| M41A/Y112A | 0.024 ± 0.002 | 0.95 ± 0.09 |
| M41K | 1.1 ± 0.1 | 7.4 ± 0.2 |
| M41F | 0.5 ± 0.1 | 0.09 ± 0.06 |
| Y112A/W82A/F88A | 0.9 ± 0.1 | 1200 ± 20 |
All data and error were obtained by fitting of two independent measurements.
