TABLE 2.

Key points

No.	Observation
1	Effectors of nutritional immunity trigger concurrent hypoferremia and hypercupremia during infection.
2	Copper is co-opted by the innate immune system for protection against several bacterial pathogens.
3	Macrophages import copper via CTR1 during infection, and ATP7A pumps copper into the phagosome to kill to E. coli and S. enterica.
4	Copper is mobilized to urine during UTI in humans, and is recapitulated in a non-human primate model of UTI.
5	Uropathogenic E. coli overcome copper toxicity in vivo by utilizing Cus efflux system and yersiniabactin.
6	CueO plays an important role in the virulence of S. enterica in a murine model of infection.
7	CopA/GolT in S. enterica exhibit bacterial strain and inoculum dose-dependent variation in contribution to fitness during infection.