Table 2:
Baseline imaging data. Median values shown, with range in parentheses.
| Imaging Finding | All Subjects (n = 40) | LME + Subjects (n = 32) | LME – Subjects (n = 8) |
|---|---|---|---|
| Any LME focus count | 3.5 (0–14) | 4 (1 – 14) | N/A |
| Nodular LME focus count | 0 (0–2) | 0 (0 – 2) | N/A |
| Spread/fill LME focus count | 3 (0–12) | 3.5 (0 – 12) | N/A |
| Spread/fill-infratentorial LME focus count | 0 (0–1) | 0 (0 – 1) | N/A |
| Spread/fill-gyral LME focus count | 2 (0–6) | 2 (0 – 6) | N/A |
| Spread/fill-sulcal LME focus count | 1 (0–10) | 1 (0 – 10) | N/A |
| Total CL count | 34 (9–87) | 35 (10 – 87) | 28 (9 – 51) |
| Total CL volume (mm3) | 429.1 (136.8–1224.3) | 520.7 (136.8 – 1370.4) | 370.9 (155.4 – 975.8) |
| Leukocortical CL count | 24 (7–65) | 24.5 (8 – 65) | 19.5 (7 – 43) |
| Leukocortical CL volume (mm3) | 316.8 (68.9–790.6) | 288.9 (68.9 – 790.6) | 255.3 (95.8 – 786.3) |
| Intracortical CL count | 6 (0–14) | 6 (0 – 14) | 3 (0 – 8)* |
| Intracortical CL volume (mm3) | 28.7 (0–115.0) | 31.3 (0 – 115.0) | 17.6 (0 – 42.7) |
| Subpial CL count | 4 (0–13) | 4 (0 – 13) | 3 (0 – 6) |
| Subpial CL volume (mm3) | 134.0 (0– 708.7) | 146.6 (0 – 708.7) | 61.0 (19.9 – 254.1) |
| Hippocampal CL count | 1 (0–7) | 1 (0 – 7) | 0 (0 – 2)* |
| Hippocampal CL volume (mm3) | 7.1 (0– 174.0) | 9.1 (0 – 174.0) | 0 (0 – 16.3)* |
| Cortical GM Volume (mm3) | 421256.1 (357884.9 – 512085.0) | 417895.3 (363331.4 – 512085.0) | 438726.4 (357884.9 – 488629.7) |
| WM Volume (mm3) | 487226.7 (402455.5– 593324.4) | 483825 (402455.5 – 593324.4) | 493106.0 (407799.0 – 541058.0) |
| WML Volume (mm3) | 2802.5 (51.7–19385.8) | 2802.5 (51.7 – 19385.8) | 3719.3 (831.0 – 15062.4) |
| pRNFL thickness (μm) | 94.5 (61.3–122.8) | 95.3 (61.0 – 123.0) | 105.0 (91.0 – 119.5) |
| mRNFL thickness (μm) | 33.4 (21.9–44.4) | 32.7 (21.9 – 40.6) | 34.7 (30.5 – 44.4) |
| GCIPL thickness (μm) | 72.7 (54.7–87.8) | 71.2 (54.7 – 87.8) | 77.3 (71.8 – 84.0)* |
| INL thickness (μm) | 31.0 (24.8–43.9) | 31.4 (24.8 – 38.9) | 29.5 (27.7 – 36.3) |
| OPL thickness (μm) | 32.3 (20.4–39.7) | 32.1 (20.4 – 38.3) | 32.8 (27.5 – 39.6) |
| ONL thickness (μm) | 61.4 (45.1–73.7) | 59.8 (45.0 – 73.7) | 61.4 (51.5 – 73.2) |
| IS thickness (μm) | 19.4 (14.6–22.4) | 19.4 (14.6 – 22.4) | 20.1 (18.7 – 21.1)* |
| OS thickness (μm) | 23.1 (19.3–29.9) | 23.4 (19.3 – 29.8) | 22.5 (19.5 – 25.1) |
| AMT (μm) | 313.6 (273.5–344.6) | 311.4 (273.5 – 344.6) | 325.2 (309.7 – 334.9)* |
*
= p value < 0.05 for rank-sum difference between those with leptomeningeal enhancement (LME +) and those without (LME −). LME: leptomeningeal enhancing foci; GM: gray matter; WM: white matter; WML: white matter lesion; pRNFL: peripapillary retinal nerve fiber layer; mRNFL: macular retinal nerve fiber layer; GCIPL: ganglion cell layer + inner plexiform layer; INL: inner nuclear layer; OPL: outer plexiform layer; ONL: outer nuclear layer; IS: inner segment; OS: outer segment; AMT: average macular thickness.