Table 3:

Correlation between baseline values for retinal layer thicknesses with LME counts, cortical lesions, and brain segmentation values.

	pRNFL	mRFNL	GCIPL	INL	OPL	ONL	IS	OS	AMT
Any LME count	−0.26	−0.10	−0.25	−0.30	0.09	−0.32	−0.08	−0.21	−0.30
Nodular count	−0.26	−0.10	−0.27	0.16	−0.28	−0.15	−0.50**†	0.23	−0.34*
Spread/Fill count	−0.14	−0.08	−0.19	−0.35*	0.17	−0.29	0.05	−0.27	−0.30
Spread/fill-infratentorial count	−0.04	−0.13	−0.07	−0.13	−0.07	−0.01	−0.10	0.17	−0.13
Spread/fill-gyral count	0.01	−0.01	−0.02	−0.24	0.11	−0.06	0.20	−0.17	−0.02
Spread/fill-sulcal count	−0.21	−0.08	−0.25	−0.31	0.17	−0.34*	−0.06	−0.28	−0.27
Total CL Volume	0.21	−0.26	−0.45**†	0.07	−0.06	−0.05	0.04	0.02	−0.34*
Leukocortical CL count	−0.24	−0.15	−0.28	0.11	−0.18	−0.15	−0.22	−0.02	−0.37*
Leukocortical CL volume	−0.16	−0.27	−0.41*	0.19	−0.20	−0.01	−0.11	0.09	−0.35*
Intracortical CL count	−0.26	−0.16	−0.32	0.11	−0.18	−0.14	−0.10	−0.01	−0.32
Intracortical CL volume	−0.24	−0.19	−0.32	0.16	−0.05	−0.01	0.17	−0.02	−0.24
Subpial CL count	−0.28	0.01	−0.30	−0.10	−0.03	0.02	0.05	−0.20	−0.19
Subpial CL volume	−0.21	−0.09	−0.34*	−0.12	0.09	−0.06	0.12	−0.09	−0.21
Hypothalamic CL count	0.21	−0.28	0.07	−0.12	0.08	−0.17	0.11	−0.26	−0.13
Hypothalamic CL volume	0.18	−0.29	−0.03	0.01	0.20	−0.09	0.19	0.06	−0.10
WM volume	0.29	0.11	0.19	−0.22	0.05	−0.11	−0.01	−0.14	0.02
WML volume	−0.33	−0.24	−0.33*	−0.03	−0.08	0.01	−0.21	0.16	−0.25
Cortical GM volume	−0.20	0.18	0.13	0.21	−0.03	−0.01	0.04	0.09	0.17

All correlations adjusted for covariates of age, sex, optic neuritis history, and use of disease modifying therapy. pRNFL: peripapillary retinal nerve fiber layer; mRNFL: macular retinal nerve fiber layer; GCIPL: ganglion cell layer + inner plexiform layer; INL: inner nuclear layer; OPL: outer plexiform layer; ONL: outer nuclear layer; IS: inner segment; OS: outer segment; AMT: average macular thickness; CL: cortical lesion: GM: gray matter; WM: white matter; WML: white matter lesion.

^*p<0.05

^**p<0.01

^†p remained <0.05 after Bonferonni correction.