Fig. 1. BCR engagement by multivalent antigen activates actin remodeling in B cells.
BCR signaling is initiated by BCR binding to antigen, which activates actin turnover and remodeling through Rho family GTPases, nucleation promoting factors, Ser/Thr kinases and motor proteins. Coreceptor molecules like CD19 also influence key steps in BCR signaling. Created with BioRender.com.