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. 2021 Nov 30;12:763760. doi: 10.3389/fimmu.2021.763760

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Copyright © 2021 Zhang, Liu, Cao, Wang, Cui, Yang, Wang and Shi

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Early myocardial ischemia reperfusion promoted myocardial apoptosis and inflammatory response. (A) Heatmap of mouse inflammatory genes between the control group and IR6h group, including Nfe2l2 and Pdcd4. (B) KEGG - enriched signaling pathways according to differentially expressed genes. (C) GO-enriched modules of biological processes. (D) Transcriptional level analysis of caspase family members. (E) GSEA-enriched signaling pathway associated with inflammation or phagocytosis. IR6h, ischemia/reperfusion treatment for 6 h KEGG, Kyoto Encyclopedia of Genes and Genomes. GO, Gene Ontology. GSEA, Gene Set Enrichment Analysis. *P < 0.05, compared to the control group.