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. 2021 Nov 30;12:763760. doi: 10.3389/fimmu.2021.763760

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Copyright © 2021 Zhang, Liu, Cao, Wang, Cui, Yang, Wang and Shi

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Nrf2 promoted the infiltration of M1 macrophages and release of inflammatory factors via initiating the transcription of Ccl3. (A) Correlation analysis between Ccl3 expression and M1 macrophage infiltration. (B) Analysis of infiltrated M1 macrophages between the low Ccl3 and high Ccl3 groups. (C) Correlation analysis between Ccl3 expression and the signature score of Ccr5⁺ M1 macrophages. (D) signature score of Ccr5⁺ M1 macrophages between the low Ccl3 and high Ccl3 groups. (E–H) The expression of inflammatory factors II1b, II16, Nfkb1, and macrophage labeling Cd11b between the low-score Ccr5⁺ M1 macrophage signature group and the high-score Ccr5⁺ M1 macrophage signature group. (I) Schematic diagram of Nrf2, cooperated with PDCD4, promoting the infiltration of M1 macrophages and release of inflammatory factors by initiating the transcription of Ccl3 in early myocardial ischemia reperfusion.