TABLE 3.

Minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) of lonafarnib and tipifarnib on S. aureus, S. epidermidis, S. pneumoniae, and E. coli.

	MIC (μM)		MBC (μM)
	Lonafarnib	Tipifarnib	Lonafarnib	Tipifarnib
S. aureus	25	500	32.5	2,500
S. epidermidis	N.d.	62.5	N.d.	500
S. pneumoniae	12.5	125	N/A	N/A
E. coli	No inhibition	No inhibition	N/A	N/A

OD₆₀₀ was measured for both strains treated with increasing concentrations of lonafarnib and tipifarnib. Concentrations used for MIC ranged from 0.78 to 100 μM (lonafarnib) and 3.6 to 500 μM (tipifarnib). Concentrations used for MBC ranged from 3.6 μM to 2.5 mM (tipifarnib) and 3.6 μM to 1 mM (lonafarnib). N.d., not determined, due to precipitations of the inhibitors the data are not evaluable.