Table 5.
Effect of bee venom using both doses (0.5 and 1.23 mg/kg) and combined therapy (metformin and atorvastatin) on body weight.
| Groups | Negative control | Positive control | Bee venom treated group(0.5 mg/kg) | Bee venom treated group (1.23 mg/kg) | Metformin- and atorvastatin- treated group | P value |
|---|---|---|---|---|---|---|
| Initial | 268.7 ± 5.8c | 134.5 ± 1.55 | 147.5 ± 1.88 | 157.4 ± 2.58c | 149.5 ± 2.31a | < 0.0001 |
| % change | ----- | −49.94% | 9.66% | 17% | 11.15% | |
| 1st week | 281.9 ± 7.65c | 132.1 ± 1.38 | 151.5 ± 1.91a | 163.9 ± 4.2c | 156.2 ± 2.59b | |
| % change | ----- | −53.14% | 14.68% | 24.07% | 18.24% | |
| 2nd week | 291.7 ± 8.76c | 127 ± 1.67 | 154.2 ± 2.17b | 166 ± 4.3c | 158.3 ± 2.49c | |
| % change | ----- | −56.46% | 21.41% | 30.7% | 24.64% | |
| 3rd week | 303.4 ± 9.77c | 119.8 ± 1.31 | 160.1 ± 2.92c | 169 ± 4.54c | 160.7 ± 2.49c | |
| % change | ----- | −60.5% | 33.63% | 41.06% | 34.14% | |
| 4th week | 314.9 ± 9.28c | 107.2 ± 2.07 | 165.5 ± 3.15c | 176 ± 4.9c | 170.3 ± 2.42c | |
| % change | ----- | −65.95% | 54.3% | 64.17% | 58.86% |
Initial means one day before administration of different treatments. Values are expressed in mean ± SEM, n= 10. Statistical analysis was performed by two-way ANOVA test followed by Tukey's post hoc test. Values with different superscript letters represent significant differences (P < 0.05). aP < 0.05, bP < 0.01, cP < 0.001 compared to positive control group. % change of positive control was calculated according to negative control. % change of all treated groups was calculated according to positive control.