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. 2021 Jul 22;41(12):3324–3338. doi: 10.1177/0271678X211033358

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© The Author(s) 2021

This article is distributed under the terms of the Creative Commons Attribution 4.0 License (https://creativecommons.org/licenses/by/4.0/) which permits any use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figure 5. — Brain region specific effects of sleep on acylcarnitines. (a) Distribution and sleep/wake differences of selected acylcarnitine conjugates in the investigated brain regions (N = 6 in each group); (b) Simplified schematic illustration of the carnitine shuttle; (c) Distribution of hydroxyoctadecanoic acid in the investigated brain regions (N = 6) and representative EICs for m/z 299.2580 ([M-H]⁻) in CTX; (d) Simplified schematic representation of the 2-hydroxylation of fatty acids and their incorporation in the myelin components 2-OH-cerebrosides and 2-OH-sulfatides. Error bars: standard deviation (SD); Two-tailed unpaired t-test: *P < 0.05, **P < 0.01, ***P < 0.001.

AcCoA: acyl-coenzyme A; CPT1/2: carnitine palmitoyltransferase 1 and 2.