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. 2021 Dec 14;43(8):2147–2155. doi: 10.1038/s41401-021-00818-x

Fig. 1. Overview of DPP4 mutant sites and kinetic curves of mutants.

Fig. 1

a The structure of DPP4 (PDB ID: 2QT9). Mutant sites were shown in spheres. The catalytic triad (S630, D708 and H740) was shown in sticks. The propeller loop (P234-G260, defined as flap in below text) was colored in marine. b, c Dipeptidyl peptidase activity of WT and mutants was determined with GlyPro-AMC as a substrate in the enzymatic activity assay. Km curve of DPP4 mutation (b) and means and standard deviations of kinetic constants are plotted (c).