Skip to main content
. 2021 Dec 14;43(8):2147–2155. doi: 10.1038/s41401-021-00818-x

Fig. 3. Analysis of the conformational changes of DPP4-WT and DPP4-V486M.

Fig. 3

a The mass center distance between the tip of flap (D243-L246) and catalytic triad (Flap-Core distance) was calculated to evaluate the conformational changes of the flap. The conformations with Flap-Core distance less than 27.5 Å refer to “close” state, and the conformations with Flap-Core distance greater than 28.4 Å refer to “open” state. b Representative structures of the “close” and “open” states.