Table 1.
Antimicrobial activity of KBP-7072 tested against the main organism groups and characterized subsets
| Organism/organism group/genotype (no. of isolates) | Number (cumulative %) of isolates inhibited at MIC (mg/L) of: |
MIC50 | MIC90 | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ≤0.015 | 0.03 | 0.06 | 0.12 | 0.25 | 0.5 | 1 | 2 | 4 | 8 | |||
| S. aureus (103) | 11 (10.7) | 56 (65.0) | 13 (77.7) | 7 (84.5) | 14 (98.1) | 2 (100.0) | 0.06 | 0.5 | ||||
| Tetracycline susceptible (52) | 7 (13.5) | 33 (76.9) | 9 (94.2) | 1 (96.2) | 2 (100.0) | 0.06 | 0.12 | |||||
| Tetracycline resistant (51) | 4 (7.8) | 23 (52.9) | 4 (60.8) | 6 (72.5) | 12 (96.1) | 2 (100.0) | 0.06 | 0.5 | ||||
| tet(M) (29) | 2 (6.9) | 5 (24.1) | 2 (31.0) | 6 (51.7) | 12 (93.1) | 2 (100.0) | 0.25 | 0.5 | ||||
| tet(K) (15) | 1 (6.7) | 12 (86.7) | 2 (100.0) | 0.06 | 0.12 | |||||||
| tet(K) + tet(M) (5) | 5 (100.0) | 0.06 | — | |||||||||
| Othera (2) | 1 (50.0) | 1 (100.0) | 0.06 | — | ||||||||
| S. pneumoniae (102) | 72 (70.6) | 30 (100.0) | ≤0.015 | 0.03 | ||||||||
| Tetracycline susceptible (51) | 31 (60.8) | 20 (100.0) | ≤0.015 | 0.03 | ||||||||
| Tetracycline resistant (51) | 41 (80.4) | 10 (100.0) | ≤0.015 | 0.03 | ||||||||
| tet(M) (50) | 40 (80.0) | 10 (100.0) | ≤0.015 | 0.03 | ||||||||
| tet(32) (1) | 1 (100.0) | — | — | |||||||||
| E. coli (103) | 3 (2.9) | 57 (58.3) | 27 (84.5) | 9 (93.2) | 7 (100.0) | 0.12 | 0.5 | |||||
| Tetracycline susceptible (51) | 3 (5.9) | 39 (82.4) | 9 (100.0) | 0.12 | 0.25 | |||||||
| Tetracycline resistant (52) | 18 (34.6) | 18 (69.2) | 9 (86.5) | 7 (100.0) | 0.25 | 1 | ||||||
| tet(A) (20) | 5 (25.0) | 7 (60.0) | 3 (100.0) | 0.25 | 0.5 | |||||||
| tet(A) + tet(B) (8) | 1 (12.5) | 4 (62.5) | 1 (75.0) | 2 (100.0) | 0.25 | — | ||||||
| tet(B) (21) | 9 (42.9) | 9 (85.7) | 1 (90.5) | 2 (100.0) | 0.25 | 0.5 | ||||||
| tet(D) (3) | 3 (100.0) | 0.12 | — | |||||||||
| K. pneumoniae (105) | 1 (1.0) | 8 (8.6) | 41 (47.6) | 22 (68.6) | 19 (86.7) | 7 (93.3) | 5 (98.1) | 2 (100.0) | 0.5 | 2 | ||
| Tetracycline susceptible (54) | 1 (1.9) | 8 (16.7) | 39 (88.9) | 6 (100.0) | 0.25 | 0.5 | ||||||
| Tetracycline resistant (51) | 2 (3.9) | 16 (35.3) | 19 (72.5) | 7 (86.3) | 5 (96.1) | 2 (100.0) | 1 | 4 | ||||
| tet(A) (40) | 2 (5.0) | 14 (40.0) | 16 (80.0) | 4 (90.0) | 2 (95.0) | 2 (100.0) | 1 | 2 | ||||
| tet(A) + tet(B) (2) | 2 (100.0) | 2 | — | |||||||||
| tet(A) + tet(G) (2) | 1 (50.0) | 1 (100.0) | 1 | — | ||||||||
| tet(D) (5) | 2 (40.0) | 1 (60.0) | 0 (60.0) | 2 (100.0) | 1 | — | ||||||
| tet(G) (2) | 1 (50.0) | 0 (50.0) | 1 (100.0) | 1 | — | |||||||
a
Contains 1 isolate with tet(L) and 1 isolate with tet(L)/tet(M).