Figure 1.

Nrf2 knockout exacerbates post-stroke depression, but not cognitive impairment, on days 21 to 28 after c-ICH. We titrated the collagenase dose injected into the Nrf2^−/− mice until the lesion size matched that in WT male mice. (a) Representative images show matching lesion sizes on day 1 after c-ICH. (b) We measured neurologic deficits with a 24-point scoring system to evaluate sensorimotor function on days 1, 3, 7, and 14 after c-ICH. n = 6 mice/group, mean ± SD, *p < 0.05 vs. WT. (c) Immobility time on the forced swim test and on the tail suspension test and the preference for sucrose over plain water were assessed during days 21–28 after sham surgery or c-ICH in male WT and Nrf2^−/− mice. (d) Discrimination index in the novel object recognition test and Y-maze test. (C, D) n = 8 male mice per group, mean ± SD, *p < 0.05 vs. sham of the same genotype; ^#p < 0.05 vs. c-ICH WT; n.s., not significant.