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. 2021 Jul 8;41(12):3288–3301. doi: 10.1177/0271678X211029060

Figure 3.

Figure 3.

TP-500 treatment ameliorates post-stroke depression after c-ICH. Mice were treated with TP-500 (2 mg/kg) or vehicle on day 7 post-ICH and then once daily until the experiment ended. (a) Flow chart illustrates the timing of TP-500 administration and behavior testing. (b) TP-500 treatment significantly reduced immobility time on the forced swim test and on the tail suspension test and increased preference for sweetened drinking water after c-ICH. n = 8 male mice per group. (c) Western blot analysis showed that expression levels of Nrf2, TrkB, and BDNF were markedly higher in the TP-500 treatment group than in the vehicle group on day 28 after c-ICH. n = 6-8 male mice per group. Values are mean ± SD; *p < 0.05 for vehicle vs. sham group; #p < 0.05 for TP-500 treatment vs. vehicle group.