Skip to main content
. 2021 Jul 8;41(12):3288–3301. doi: 10.1177/0271678X211029060

Figure 6.

Figure 6.

TP-500 treatment regulates TrkB downstream MAPK and PI3K pathways 28 days after c-ICH. (a and b) Western blots showed decreased expression of phosphorylated p-38 (p-p38) and increased expression of phosphorylated ERK1/2 (p-ERK1/2) after TP-500 treatment. These changes were abolished by co-administration of ANA-12. (c and d) Western blots showed increased expression of PI3K and phosphorylated AKT (p-AKT) after TP-500 treatment. Similarly, these changes were abolished by co-administration of ANA-12. n = 4-6 male mice per group. Values are mean ± SD. *P < 0.05 TP-500&vehicle vs. TP-500&ANA-12 group. #P < 0.05 TP-500&vehicle vs. c-ICH group.