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. 2021 Jul 8;41(12):3288–3301. doi: 10.1177/0271678X211029060

Figure 7.

Figure 7.

Sex does not affect the expression level of Nrf2 or the therapeutic effect of TP-500. (a) First, we titrated the collagenase injected into the female mice to match the lesion volume of male mice. Representative images show that a higher dose of collagenase was needed in female mice (0.35 μL, 0.053 U vs. 0.30 μL, 0.045 U) to match the lesion volume on day 1 after c-ICH. n = 6 mice/group. (b) Immobility time on the forced swim test and on the tail suspension test and preference for sweetened drinking water during days 21–28 after c-ICH was altered to a greater extent in female than in male WT mice. n = 8 mice per group. *p < 0.05 vs. same sex sham; #p < 0.05 for female vs. male after c-ICH. (c) Western blots show that expression levels of Nrf2, TrkB, and BDNF were similar in male and female sham mice and decreased to a similar extent after c-ICH in the two sexes. n = 6 mice/group. (d) In female mice, TP-500 decreased immobility time on the forced swim test and on the tail suspension test and increased preference for sucrose in the drinking water during days 21–28 after c-ICH. n = 8 mice per group. Values are mean ± SD; *p < 0.05 for TP-500 treatment vs. vehicle group; n.s., not significant.