Table 2.

Clusters showing significant longitudinal GMV changes in the LHS and RHS patient groups, respectively.

	Significant clusters		Size	Corrected p-value	Location(approximate)	p-values in patient sub-groups
						Cortical(24 patients)	Cortico-subcortical(16 patients)	Subcortical(12 patients)
LHS	Ipsilesional(LH)	increased cluster 1	1,654 mm3	0.01	Dorsal precuneus	0.438	9.2 × 10-5*	0.002*
		decreased cluster 1	2,467 mm3	0.008	Medial orbital frontal gyrus	0.008*	8.8 × 10-4*	0.011*
		decreased cluster 2	2,153 mm3	0.01	Middle cingulate cortex	0.089	8.8 × 10-4*	0.011*
	Contralesional(RH)	increased cluster 1	41,691 mm3	<0.0001	Precuneus & adjacent areas	0.009*	0.002*	0.012*
		increased cluster 2	24,840 mm3	<0.0001	Large frontal areas	0.129	4.5 × 10-5*	0.006*
		decreased cluster 1	11,684 mm3	0.001	cerebellum	0.001*	0.019*	0.029*
	Significant clusters		Size	Corrected p-value	Location(approximate)	p-values in patient sub-groups
						Cortical(13 patients)	Cortico-subcortical(16 patients)	Subcortical(16 patients)
RHS	Ipsilesional (RH)	increased cluster 1	7,796 mm3	0.001	Medial superior/orbital gyri	0.174	0.005*	3.0 × 10-5*
		increased cluster 2	1,742 mm3	0.01	Precuneus & adjacent areas	5.8 × 10-4*	0.001*	0.158
		decreased cluster 1	4,587 mm3	0.003	Medial orbital frontal gyrus	0.025*	8.4 × 10-4*	0.031*
		decreased cluster 2	3,918 mm3	0.004	Middle cingulate cortex	0.004*	5.4 × 10-4*	0.040*
	Contralesional (LH)	increased cluster 1	59,356 mm3	<0.0001	Large frontal areas	0.020*	8.7 × 10-6*	0.011*
		increased cluster 2	12,879 mm3	0.001	Precuneus + adjacent areas	2.1 × 10-5*	0.001*	0.972
		increased cluster 3	12,380 mm3	0.002	Inferior parietal gyrus	0.020*	6.4 × 10-4*	1.4 × 10-4*

LH: left hemisphere; RH: right hemisphere; LHS: left hemisphere stroke; RHS: right hemisphere stroke. Three patient subgroups of categorical lesion location were tested: cortical, cortico-subcortical, subcortical subgroups. The other subgroups of categorical lesion location were not tested due to their too small sample size. The vast majority of the clusters identified from all patients also showed significant GMV changes in these subgroups (*p < .05). For detailed locations of each cluster, please see Figure 2.The significance for the values shown in bold is indexed by *.