FIG 2.

The core response of CUG clade species primarily consists of alternative carbon metabolism genes. (A) Violin plot of the log₂ fold change (LFC) of the 92 genes showing significant induction (FDR = 0.1) across at least five species. Box plots showing median and quartiles are superimposed. The dashed line indicates an LFC of 1 (2-fold induction). (B) Selected enriched GO terms (top) and Mig1/Mig2 regulon inclusion (bottom) among core induced genes depicted in panel A. Analysis was performed using C. albicans orthologs, and the 4,376 conserved genes were the background gene set. FDR-adjusted P values for GO term enrichment are shown. The P value for Mig1/Mig2 regulon inclusion is from a hypergeometric test comparing core induced and total genes. (C) Examples of individual alternative carbon metabolism genes demonstrating conserved phagocytosis-dependent induction.