TABLE 2.

Effects of ivacaftor on clinical parameters and inflammation^a

Parameter	Mean	No.	Change from baseline
			Mean	95% CI	P value (adj)
Sweat chloride (mM)
Baseline	80.44	9
2 days	50.33	9	−30.11	(−41.70 to −18.53)	0.0002
7 days	55.88	8	−24.57	(−35.99 to −13.14)	0.0008
2.5 yrs	42.13	8	−38.32	(−62.61 to −14.03)	0.0050
FEV1 (% predicted)
Baseline	64.98	10
2 days	68.87	10	3.88	(0.35 to 7.41)	0.03
7 days	71.98	10	7.00	(1.68 to 12.33)	0.01
2.5 yrs	71.14	8	6.16	(−1.34 to 13.66)	0.11
Neutrophil elastase (log10 ug/mL)
Baseline	1.76	10
2 days	1.51	10	−0.25	(−1.12 to 0.60)	0.86
7 days	1.07	9	−0.69	(−1.39 to −0.003)	0.049
2.5 yrs	1.04	7	−0.72	(−2.17 to 0.72)	0.38
IL-1β (log10 pg/mL)
Baseline	3.69	10
2 days	3.66	10	−0.03	(−0.92 to 0.85)	0.99
7 days	3.38	9	−0.31	(−1.21 to 0.60)	0.79
2.5 yrs	2.60	7	−1.09	(−2.63 to 0.44)	0.17
IL-8 (log10 pg/mL)
Baseline	4.68	10
2 days	4.70	10	0.02	(−0.71 to 0.75)	>0.99
7 days	4.50	9	−0.19	(−1.08 to 0.71)	0.97
2.5 yrs	4.16	7	−0.52	(−1.64 to 0.60)	0.48
MacConkey (log10 CFU/mL) (presumptive Pa)
Baseline	6.62	5
2 days	6.26	5	−0.37	(−2.50 to 1.77)	0.96
7 days	5.61	4	−1.02	(−3.59 to 1.56)	0.41
2.5 yrs	3.34	3	−3.28	(−8.42 to 1.85)	0.12
MSA (log10 CFU/mL) (presumptive Sa)
Baseline	5.31	7
2 days	4.98	7	−0.33	(−2.35 to 1.69)	0.99
7 days	4.19	6	−1.11	(−2.11 to −0.12)	0.03
2.5 yrs	3.49	4	−1.82	(−6.33 to 2.68)	0.40

^aCI, confidence interval; adj, adjusted for multiple comparisons; FEV1, forced expiratory volume in 1 second; IL, interleukin; Pa, Pseudomonas aeruginosa; MSA, mannitol salt agar; Sa, Staphylococcus aureus.