Identification of L257F variant in a patient with SLE. (A) P2RY8 +/L257F variant viewed by Integrative Genomics Viewer. The green bars represent bases Ts that did not match the reference bases Cs. (B and C) Familial-relatedness (B) and ancestry (C) check using Peddy. Ped Coef, Peddy relatedness coefficient. Coefficients of 0.5 (parents-offspring or full siblings) and 0 (unrelated). (D) Illustration of tolerance of missense variants in P2RY8 gene (Wiel et al., 2019). AFR, African/African American; AMR, American Admixed/Latino; EUR, European; SAS, South Asian.