Table 2. Pretreatment and Posttreatment Measures.
| Characteristic | ICS | ICS/LABA | Placebo | |||
|---|---|---|---|---|---|---|
| Pretreatment | Posttreatment | Pretreatment | Posttreatment | Pretreatment | Posttreatment | |
| Spirometry | ||||||
| No. | 20 | 18 | 19 | 17 | 14 | 13 |
| %FEV1, mean (SD) | 75.1 (8.0) | 81.1 (12.3) | 77.9 (7.9) | 86.2 (6.4) | 72.4 (11.2) | 71.2 (12.1) |
| %FEV1 ≤85%, No. (%) | 20 (100) | 11 (61) | 19 (100) | 8 (47) | 14 (100) | 13 (100) |
| %FEF25%-75%, mean (SD) | 48.1 (15.2) | 57.6 (15.1) | 54.6 (19.4) | 70.8 (17.0) | 48.1 (21.7) | 48.2 (23.4) |
| %FVC, mean (SD) | 91.0 (10.5) | 91.9 (14.3) | 91.8 (8.3) | 91.9 (11.0) | 90.0 (7.3) | 88.8 (12.2) |
| FEV1/FVC, mean (SD) | 0.73 (0.10) | 0.78 (0.08) | 0.75 (0.11) | 0.83 (0.08) | 0.71 (0.12) | 0.71 (0.14) |
| PEFR, % predicted, mean (SD) | 81.3 (13.5) | 95.5 (16.3) | 81.6 (15.5) | 102.0 (14.1) | 75.4 (10.8) | 79.5 (10.4) |
| FENO | ||||||
| No. | 20 | 18 | 19 | 17 | 14 | 13 |
| FENO, mean (SD), ppb | 29.8 (31.4) | 15.8 (9.8) | 25.2 (23.8) | 15.9 (14.2) | 26.4 (27.4) | 24.2 (25.5) |
| FENO >30 ppb, No. (%) | 7 (35) | 1 (6) | 5 (26) | 1 (6) | 4 (29) | 4 (31) |
| Exercise capacity | ||||||
| No. | 16 | 14 | 18 | 16 | 13 | 11 |
| Peak heart rate, mean (SD), bpm | 185.3 (10.7) | 181.8 (14.1) | 189.3 (14.8) | 187.9 (11.2) | 189.1 (8.7) | 177.8 (17.0) |
| Peak respiratory rate, mean (SD), bpm | 62.0 (10.9) | 63.2 (10.1) | 65.6 (7.2) | 63.7 (10.3) | 58.5 (10.6) | 60.0 (12.4) |
| Relative workload, mean (SD), watts/kg | 2.2 (0.5) | 2.2 (0.5) | 2.5 (0.6) | 2.5 (0.5) | 2.2 (0.5) | 2.2 (0.5) |
| Relative peak O2 uptake, mean (SD), mL/kg/min | 30.6 (5.8) | 31.8 (6.2) | 33.2 (6.2) | 34.0 (7.2) | 31.8 (5.8) | 30.7 (5.4) |
| Relative peak CO2 production, mean (SD), mL/kg/min | 35.6 (7.6) | 36.2 (8.2) | 38.7 (8.7) | 40.1 (8.2) | 37.1 (7.6) | 35.2 (8.3) |
| VE, L (SD) | 45.3 (13.5) | 50.9 (16.3) | 53.0 (16.7) | 54.1 (17.9) | 51.3 (11.5) | 50.6 (14.6) |
| Relative V̇E, mean (SD), L/kg | 1.2 (0.3) | 1.4 (0.6) | 1.4 (0.4) | 1.5 (0.3) | 1.3 (0.2) | 1.3 (0.3) |
| VE vs height, mean (SD), L/m | 31.6 (7.6) | 35.5 (10.9) | 36.1 (9.8) | 36.7 (9.6) | 34.7 (5.6) | 33.8 (8.2) |
| Highest RER, mean (SD) | 1.2 (0.1) | 1.2 (0.1) | 1.2 (0.1) | 1.2 (0.1) | 1.2 (0.1) | 1.2 (0.1) |
| Breathing reserve maximum, mean (SD), % | 17.9 (18.5) | 21.5 (20.6) | 15.5 (17.0) | 20.6 (18.8) | 9.1 (15.4) | 13.5 (15.6) |
Abbreviations: %FEF25%-75%, forced midexpiratory flow of 25% to 75% of FVE; FENO, fractional exhaled nitric oxide; %FEV1, percent predicted forced expiratory volume in 1 second; FVC, forced vital capacity; ICS, inhaled corticosteroids; LABA, long-acting β2 agonist; PEFR, peak expiratory flow rate; RER, respiratory exchange ratio; V̇E, minute ventilation.