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. 2021 Dec 13;182(2):1–11. doi: 10.1001/jamainternmed.2021.7009

Table 1. Characteristics of Included Studies.

Study (location) Period Setting Recruitment Follow-up Dementia Mortality
Sample Response rate, % Included or excluded individuals Source of outcome data Assessment Maximum follow-up time, y Diagnosis Lost to follow-up, % Maximum follow-up time, y Verification
ZARADEMP (Zaragoza, Spain)16 1994-1999 Community dwelling and institutionalized Random census sample stratified by age and sex 79 Included: aged ≥55 y Follow-up cognitive screening and municipal death registry Every 2 y 4 Psychiatrist-confirmed DSM-IV diagnosisa 10 13 Verified by death records
SNAC-K (Stockholm, Sweden)17 2001-2020 Community dwelling and institutionalized Random population sample stratified by age; multiple cohorts 73 Included: aged ≥60 y Follow-up cognitive screening, medical registries, informant interviews, and death certificates
  • Every 6 y (for those aged <78 y)

  • 3-yearly (for aged ≥78 y)

12 2nd independent physician–confirmed DSM-III-R diagnosis 11 16 Verified by death records
Kungsholmen Project (Stockholm, Sweden)18 1987-1996 Community dwelling and institutionalized Kungsholmen district (75+) 76 Included: aged ≥75 y Follow-up cognitive screening, medical registries, informant interviews, and death certificates Every 3 y 9 2nd independent physician–confirmed DSM-III-R diagnosis 12 11 Verified by death records
LEILA 75+ (Leipzig, Germany)19 1997-2014 Community dwelling and institutionalized Representative population sample 75 Included: aged ≥75 y Follow-up cognitive screening, death certificates, and relative interviews Every 1.5 y 16 Expert panel–confirmed DSM-III-R or DSM-IV diagnosis 9 16 Verified by death records
H70 (Gothenburg, Sweden)20 2000-2012 Community dwelling and institutionalized Representative population samples; 1930 cohorts 72 Included: aged 70, 75, and 79 y Follow-up cognitive screening, medical registries, informant interviews, and death records Every 5 y 12 DSM-III-R diagnosis 0 12 Verified by death records
PreDIVA (Amsterdam, the Netherlands)21 2006-2015 Community dwelling only General practice populations (>98% Dutch population is registered with a general practitioner) 53
  • Included: aged 70-78 y

  • Excluded: with (possible) dementia and limited life expectancy (eg, terminal disease)

Follow-up cognitive screening, EHRs, and municipal death records Every 2 y 9 Expert panel–confirmed DSM-IV diagnosis 2 9 Verified by death records
ACT (Seattle, Washington)22 1994-2020 Community dwelling only Random health insurance sample (representative of local population) 48
  • Included: aged ≥65 y

  • Excluded: with (possible) dementia

Follow-up cognitive screening, medical records, and death certificates Every 2 y 25 Expert panel–confirmed DSM-IV diagnosis 3 25 Verified by death records

Abbreviations: ACT, Adult Changes in Thought; DSM-III-R, Diagnostic and Statistical Manual of Mental Disorders (Third Edition Revised); DSM-IV, Diagnostic and Statistical Manual of Mental Disorders (Fourth Edition); EHR, electronic health record; H70, Gothenburg H70 Birth Cohort Study; LEILA 75+, Leipzig Longitudinal Study of the Aged; PreDIVA, Prevention of Dementia by Intensive Vascular Care; SNAC-K, Swedish National Study of Aging and Care in Kungsholmen; ZARADEMP, Zaragoza Dementia Depression Project.

a

No dementia information was available for individuals between last assessment and death or study dropout.