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. 2021 Nov 30;9:780023. doi: 10.3389/fcell.2021.780023

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Copyright © 2021 She, Shao and Jia.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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SRSF6 expression and function were regulated at multiple levels, including transcription, alternative splicing, mRNA stability, protein stability and function. Tumor suppressor p53 may inhibit SRSF6 transcription. SRSF6 itself, SRSF4, and SRSF5 inhibit SRSF6 exon 3 exclusion to produce a transcript with exon 3, which is a target of NMD or encode a truncated SRSF6 protein. Transcripts without exon 3 encode full-length SRSF6, and were inhibited by microRNA miR-128-5p, miR-26a-3p, and miR-66a, but rescued by lncRNA ZNF561-AS1, circRNA circFBXL5 via ceRNA mechanism. SRSF6 protein can be suppressed by lncRNA LINC01133. SRSF6 can be degraded via ubiquitination-proteasome. LncRNA CRNDE promotes SRSF6 ubiquitination, however, USP7 deubiquitinase can protect SRSF6 from ubiquitination and degradation.