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Methods of inhibiting SRSF6 expression and functions. Indacaterol suppresses SRSF6 by binding to RRM2 domain. Zn2+ can induce hyperphosphorylation of RS domain and abolish its RNA binding ability. SRSF6 mRNAs can be targeted and degraded by siRNAs. Decoy RNAs with SRSF6 binding motifs may block SRSF6 function. Antisense oligonucleotides targeting potential exonic splicing suppressor (ESS) or intron splicing suppressor (ISS) in or around exon 3 may promote exon 3 inclusion.
