TABLE 2.

List of network interactions.

Upstream molecule	Downstream molecule	Interaction type a	PMID	Reference
ALOX12	RXR-α	pos	24963038	Sharma et al. (2014)
ALOX15	RXR-α	pos	24963038	Sharma et al. (2014)
ALOX5	RXR-α	pos	24963038	Sharma et al. (2014)
APLN	miR-424-5p	pos	23263626	Kim et al. (2013)
APLN	miR-503-5p	pos	23263626	Kim et al. (2013)
CASC2	miR-222-3p	neg	32206065	Han et al. (2020)
CCND1	miR-17-5p	pos	18695042	Yu et al. (2008)
CCND1	miR-19a-3p	pos	28090171	Inoue and Fry. (2015)
CCND1	miR-20a-5p	Pos	28090171	Inoue and Fry. (2015)
CPS1-IT	IL-1β	neg	30982984	Zhang et al. (2019b)
CREB1	MCU	pos	27648837	Hong et al. (2017)
H19	let-7b-5p	neg	30547791	Su et al. (2018)
HDAC4	miR-424-5p	neg	29102771	Takagi et al. (2018)
HDAC4	miR-503-5p	neg	29102771	Takagi et al. (2018)
HDAC5	miR-424-5p	neg	29102771	Takagi et al. (2018)
HDAC5	miR-503-5p	neg	29102771	Takagi et al. (2018)
HIF-1α	let-7b-3p	pos	30628484	Zhang H et al. (2019)
HIF-1α	miR-145-5p	pos	25129238	Agrawal et al. (2014)
HIF-1α	miR-191-5p	pos	25119596	Song et al. (2014)
HIF-1α	miR-195-5p	pos	28862358	Zeng et al. (2018)
HIF-1α	miR-19a-3p	pos	31682848	Zhao et al. (2019)
HIF-1α	miR-205-5p	pos	23924028	Gandellini et al. (2014)
HIF-1α	miR-210-3p	neg	22886504	Gou et al. (2012)
HIF-1α	miR-214-3p	pos	24011070	el Azzouzi et al. (2013)
HIF-1α	miR-223-3p	neg	26084306	Meloche et al. (2015a)
HIF-1α	miR-27a-3p	pos	24517586	Camps et al. (2014)
HIF-1α	miR-361-5p	pos	29339076	Zhang Y et al. (2018)
HOXA-AS3	HOXA3	pos	30304383	Zhang R et al. (2019)
Hsa_circ_0016070	miR-942-5p	neg	31593832	Zhou et al. (2019)
JARID1B	MANTIS	neg	2,8351900	Leisegang et al. (2017)
let-7a	STAT3	neg	32803651	Cheng et al. (2020)
let-7b-3p	ACE2	neg	30628484	Zhang Y et al. (2019)
let-7b-5p	AT1R	neg	30547791	Su et al. (2018)
let-7b-5p	ET-1	neg	24978044	Guo et al. (2014)
let-7b-5p	TGFBR1	neg	24978044	Guo et al. (2014)
let-7g	MYC	neg	27889560	Zhang W.-F et al. (2017)
LincRNA-Cox2	let-7a	neg	32803651	Cheng et al. (2020)
LncRNA-Ang362	miR-221-3p	pos	31313741	Wang et al. (2020)
LncRNA-Ang362	miR-222-3p	pos	31313741	Wang et al. (2020)
LRP8	POU5F1	neg	26565914	Bertero et al. (2015)
MALAT1	miR-124-3p	neg	31257528	Wang S et al. (2019)
MANTIS	BRG1	pos	2,8351900	Leisegang et al. (2017)
MEG3	miR-328-3p	neg	31477557	Xing X.-Q et al. (2019)
miR-100-5p	MTOR	neg	26409044	Wang et al. (2015)
miR-103a-3p	HIF-1β	neg	26827991	Deng et al. (2016)
miR-107-3p	HIF-1β	neg	26827991	Deng et al. (2016)
miR-107-3p	NOR1	neg	31933977	Chen et al. (2019)
miR-1181	STAT3	neg	30211651	Qian et al. (2018)
miR-124-3p	CAMTA1	neg	23853098	Kang K et al. (2013)
miR-124-3p	GRB2	neg	28496318	Li Y et al. (2017)
miR-124-3p	KLF5	neg	31257528	Wang D et al. (2019)
miR-124-3p	NFATC1	neg	23853098	Kang B.-Y et al. (2013)
miR-124-3p	PTBP1	neg	23853098	Kang K et al. (2013)
miR-124-3p	PTBP1	neg	24122720	Wang et al. (2014)
miR-124-3p	PTBP1	neg	2,8971999	Caruso et al. (2017)
miR-124-3p	PTBP1	neg	2,8972001	Zhang H et al. (2017)
miR-125a-5p	BMPR2	neg	25854878	Huber et al. (2015)
miR-125a-5p	MFN1	neg	28593577	Ma et al. (2017)
miR-125a-5p	STAT3	neg	29700287	Cai et al. (2018)
miR-1268a	CDKN2A(P16)	neg	31370272	Lee and Kang. (2019)
miR-1281	HDAC4	neg	29514810	Li et al. (2018)
miR-130a-3p	BMPR2	neg	28755990	Li L et al. (2017)
miR-130a-3p	CDKN1A(P21)	neg	25681685	Brock et al. (2015)
miR-130a-3p	LRP8	neg	26565914	Bertero et al. (2015)
miR-130a-3p	PPARγ	neg	24960162	Bertero et al. (2014)
miR-130a-3p	PPARγ	neg	26565914	Bertero et al. (2015)
miR-130b-3p	LRP8	neg	26565914	Bertero et al. (2015)
miR-130b-3p	PPARγ	neg	24960162	Bertero et al. (2014)
miR-130b-3p	PPARγ	neg	26565914	Bertero et al. (2015)
miR-132-3p	PTEN	neg	30896881	Zeng et al. (2019)
miR-135a-5p	TRPC1	neg	30038339	Liu A et al. (2019)
miR-138-5p	CREB1	neg	27648837	Hong et al. (2017)
miR-138-5p	MCU	neg	27648837	Hong et al. (2017)
miR-138-5p	MST1	neg	23485012	Li et al. (2013)
miR-138-5p	TASK-1	neg	29257242	Liu G et al. (2018)
miR-1-3p	SPHK1	neg	29167124	Sysol et al. (2018)
miR-140-5p	DNMT1	neg	27021683	Zhang and Xu. (2016)
miR-140-5p	SMURF1	neg	27214554	Rothman et al. (2016)
miR-140-5p	TNF-α	neg	30367500	Zhu et al. (2019b)
miR-143-3p	ABCA1	neg	30195228	Yue et al. (2018)
miR-141-5p	RHOA	neg	32559140	Lei et al. (2020)
miR-145-5p	ABCA1	neg	30195228	Yue et al. (2018)
miR-150-5p	HIF-1α	neg	28715868	Chen M et al. (2017)
miR-150-5p	NFATC3	neg	30551428	Li et al. (2019)
miR-15a-5p	VEGF	neg	31894295	Zhang et al. (2020)
miR-17-5p	BMPR2	neg	19390056	Brock et al. (2009)
miR-17-5p	CDKN1A(P21)	neg	30305109	Liu J. J et al. (2018)
miR-17-5p	MFN2	neg	27640178	Lu et al. (2016)
miR-17-5p	PAI-1	neg	29644896	Chen K.-H et al. (2018)
miR-17-5p	PDLIM5	neg	25647182	Chen et al. (2015)
miR-17-5p	PHD2	neg	27919930	Chen et al. (2016)
miR-17-5p	PTEN	neg	30305109	Liu G et al. (2018)
miR-182-3p	MYADM	neg	32373233	Sun et al. (2020)
miR-190a-5p	KCNQ5	neg	24446351	Li et al. (2014)
miR-190a-5p	KLF15	neg	30538440	Jiang et al. (2018)
miR-191-5p	BMPR2	neg	31119161	Zhang Z et al. (2019)
miR-193-3p	ALOX12	neg	24963038	Sharma et al. (2014)
miR-193-3p	ALOX15	neg	24963038	Sharma et al. (2014)
miR-193-3p	ALOX5	neg	24963038	Sharma et al. (2014)
miR-193-3p	IGF1R	neg	24963038	Sharma et al. (2014)
miR-195-5p	SMAD7	neg	28862358	Zeng et al. (2018)
miR-199a-5p	SMAD3	neg	27038547	Liu H et al. (2016)
miR-199b-5p	GSK3B	neg	27188753	Wu et al. (2016)
miR-19a-3p	PAI-1	neg	29644896	Chen T et al. (2018)
miR-19a-3p	PTEN	neg	31682848	Zhao et al. (2019)
miR-19b-3p	PAI-1	neg	29644896	Chen K.-H et al. (2018)
miR-200c-3p	MAP2	neg	29044995	Yuan et al. (2017)
miR-200c-3p	ZEB1	neg	29044995	Yuan et al. (2017)
miR-203a-3p	FGF2	neg	30575929	Wang et al. (2018)
miR-204-5p	ATG7	neg	31542480	Liu H.-M et al. (2019)
miR-204-5p	BRD4	neg	26224795	Meloche et al. (2015a)
miR-204-5p	FOXM1	neg	29290032	Bourgeois et al. (2018b)
miR-204-5p	RUNX2	neg	27149112	Ruffenach et al. (2016)
miR-204-5p	SHP2	neg	21321078	Courboulin et al. (2011)
miR-204-5p	TGFBR2	neg	29196166	Yu et al. (2018)
miR-205-5p	MICAL2	neg	30853343	Tao et al. (2019)
miR-206	Notch3	neg	23071643	Jalali et al. (2012)
miR-206	HIF-1α	neg	23628900	Yue et al. (2013)
miR-20a-5p	BMPR2	neg	19390056	Brock et al. (2009)
miR-20a-5p	PAI-1	neg	29644896	Chen T et al. (2018)
miR-20a-5p	PDLIM5	neg	25647182	Chen et al. (2015)
miR-20a-5p	PHD2	neg	27919930	Chen et al. (2016)
miR-210-3p	E2F3	neg	22886504	Gou et al. (2012)
miR-210-3p	ISCU1/2	neg	25825391	White et al. (2015)
miR-210-3p	MKP-1	neg	25044272	Jin et al. (2015)
miR-214-3p	ARHGEF12	neg	31373336	Xing Y et al. (2019)
miR-214-3p	CCNL2	neg	27381447	Liu Y et al. (2016)
miR-214-3p	LMOD1	neg	27144530	Sahoo et al. (2016)
miR-214-3p	MEF2C	neg	27144530	Sahoo et al. (2016)
miR-214-3p	PTEN	neg	28684904	Liu et al. (2017)
miR-21-5p	DDAH1	neg	24895913	Iannone et al. (2014)
miR-21-5p	PDCD4	neg	28522568	Green et al. (2017)
miR-21-5p	PTEN	neg	26208095	Green et al. (2015)
miR-21-5p	RHOB	neg	22371328	Parikh et al. (2012)
miR-221-3p	AXIN2	neg	28694128	Nie et al. (2019)
miR-222-3p	ING5	neg	32206065	Han et al. (2020)
miR-222-3p	CDKN1B(P27)	neg	28854428	Xu et al. (2017)
miR-222-3p	TIMP3	neg	28854428	Xu et al. (2017)
miR-223-3p	ITGB3	neg	30507047	Liu et al. (2019a)
miR-223-3p	MLC2	neg	27121304	Zeng et al. (2016)
miR-223-3p	PARP1	neg	26084306	Meloche et al. (2015b)
miR-223-3p	RHOB	neg	27121304	Zeng et al. (2016)
miR-23a-3p	BMPR2	neg	29864909	Zhang X et al. (2018)
miR-26b-5p	CCND1	neg	2,7322082	Wang P et al. (2016)
miR-26b-5p	CTGF	neg	2,7322082	Wang R et al. (2016)
miR-26b-5p	CTGF	neg	28816418	Zhou et al. (2018)
miR-27a-3p	PPARγ	neg	24244514	Kang B.-Y et al. (2013)
miR-27a-3p	PPARγ	neg	28484848	Xie et al. (2017)
miR-27a-3p	SMAD5	neg	31004656	Liu et al. (2019b)
miR-27b-3p	PPARγ	neg	25795136	Bi et al. (2015)
miR-27b-3p	PPARγ	neg	28484848	Xie et al. (2017)
miR-29b-3p	KCNA5	neg	31553627	Babicheva et al. (2020)
miR-301a-3p	LRP8	neg	26565914	Bertero et al. (2015)
miR-301a-3p	PPARγ	neg	24960162	Bertero et al. (2014)
miR-301a-3p	PPARγ	neg	26565914	Bertero et al. (2015)
miR-301b-3p	LRP8	neg	26565914	Bertero et al. (2015)
miR-301b-3p	PPARγ	neg	24960162	Bertero et al. (2014)
miR-301b-3p	PPARγ	neg	26565914	Bertero et al. (2015)
miR-30a-5p	YKL-40	neg	31115541	Tan et al. (2019)
miR-30c-5p	PDGFRβ	neg	25882492	Xing et al. (2015)
miR-328-3p	CaV1.2	neg	22392900	Guo et al. (2012)
miR-328-3p	IGF1R	neg	22392900	Guo et al. (2012)
miR-328-3p	IGF1R	neg	31477557	Xing X.-Q et al. (2019)
miR-328-3p	PIM-1	neg	27448984	Qian et al. (2016)
miR-339-5p	FRS2	neg	28947594	Chen J et al. (2017)
miR-34-5p	PDGFRα	neg	27302634	Wang P et al. (2016)
miR-34a-3p	MIEF1	neg	29431643	Chen K.-H et al. (2018)
miR-34a-3p	MIEF2	neg	29431643	Chen T et al. (2018)
miR-361-5p	ABCA1	neg	29339076	Zhang Y et al. (2018)
miR-424-5p	FGF2	neg	23263626	Kim et al. (2013)
miR-424-5p	FGF2	neg	24960162	Bertero et al. (2014)
miR-424-5p	FGFR1	neg	23263626	Kim et al. (2013)
miR-424-5p	RICTOR	neg	29102771	Takagi et al. (2018)
miR-449a-5p	MYC	neg	30715622	Zhang et al. (2019a)
miR-454-3p	LRP8	neg	26565914	Bertero et al. (2015)
miR-454-3p	PPARγ	neg	26565914	Bertero et al. (2015)
miR-4632-3p	CJUN	neg	28701355	Qian et al. (2017)
miR-495-3p	VEZF1	neg	31030195	Fu et al. (2019)
miR-497-5p	CDKN2B(P15)	neg	31370272	Lee and Kang. (2019)
miR-503-5p	FGF2	neg	23263626	Kim et al. (2013)
miR-503-5p	FGF2	neg	24960162	Bertero et al. (2014)
miR-503-5p	FGFR1	neg	23263626	Kim et al. (2013)
miR-503-5p	RICTOR	neg	29102771	Takagi et al. (2018)
miR-637	CDK6	neg	27794186	Sang et al. (2016)
miR-665	CDKN1A(P21)	neg	31370272	Lee and Kang. (2019)
miR-760	TLR4	neg	30226538	Yang et al. (2018)
miR-92b-3p	USP28	neg	30149918	Hao et al. (2018)
miR-942-5p	CCND1	neg	31593832	Zhou et al. (2019)
miR-96-5p	5-HT1B	neg	25871906	Wallace et al. (2015)
miR-98-5p	ALK1	neg	31322216	Li et al. (2019)
miR-98-5p	ET-1	neg	26098770	Kang et al. (2016)
MYC	miR-19a-3p	pos	17943719	Schulte et al. (2008)
MYC	miR-19b-3p	pos	17943719	Schulte et al. (2008)
MYC	miR-34a-3p	neg	18066065	Chang et al. (2008)
NFATC3	miR-23a-3p	pos	19574461	Lin et al. (2009)
NF-κB	miR-130a-3p	pos	28755990	Li Q et al. (2017)
NF-κB	miR-210-3p	pos	25341039	Liu et al. (2014)
NF-κB	miR-27a-3p	pos	28484848	Xie et al. (2017)
NF-κB	miR-27b-3p	pos	28484848	Xie et al. (2017)
PARP-1	STAT3	pos	24270264	Meloche et al. (2014)
PAXIP1-AS1	PXN	pos	30450722	Jandl et al. (2019)
POU5F1	miR-130a-3p	pos	24960162	Bertero et al. (2014)
POU5F1	miR-130a-3p	pos	26565914	Bertero et al. (2015)
POU5F1	miR-130b-3p	pos	24960162	Bertero et al. (2014)
POU5F1	miR-130b-3p	pos	26565914	Bertero et al. (2015)
POU5F1	miR-301a-3p	pos	24960162	Bertero et al. (2014)
POU5F1	miR-301a-3p	pos	26565914	Bertero et al. (2015)
POU5F1	miR-301b-3p	pos	24960162	Bertero et al. (2014)
POU5F1	miR-301b-3p	pos	26565914	Bertero et al. (2015)
POU5F1	miR-454-3p	pos	26565914	Bertero et al. (2015)
PPARγ	APLN	pos	24960162	Bertero et al. (2014)
PPARγ	miR-204-5p	pos	24960162	Bertero et al. (2014)
PPARγ	miR-21-5p	neg	26208095	Green et al. (2015)
PPARγ	miR-21-5p	neg	28522568	Green et al. (2017)
PPARγ	miR-27a-3p	neg	24244514	Kang K et al. (2013)
PPARγ	miR-98-5p	pos	26098770	Kang et al. (2016)
PPARγ	POU5F1	neg	26565914	Bertero et al. (2015)
RUNX2	HIF-1α	pos	27149112	Ruffenach et al. (2016)
RXR-α	miR-193-3p	neg	24963038	Sharma et al. (2014)
SMILR	miR-141-5p	neg	32559140	Lei et al. (2020)
STAT3	miR-17-5p	pos	19390056	Brock et al. (2009)
STAT3	miR-204-5p	neg	23975026	Xu et al. (2013)
STAT3	miR-20a-5p	pos	19390056	Brock et al. (2009)
STAT3	miR-34a-3p	neg	24642471	Rokavec et al. (2014)
TGF-β1	miR-143-3p	pos	2,6311719	Deng et al. (2015)
TGF-β1	miR-199a-5p	pos	20705240	Davis et al. (2010)
TGF-β1	miR-21-5p	pos	20705240	Davis et al. (2010)
TUG1	miR-328-3p	neg	31679623	Wang D et al. (2019)
TYKRIL	PDGFRβ	pos	32634060	Zehendner et al. (2020)
UCA1	ING5	neg	30353369	Zhu et al. (2019a)
ZEB1	miR-200c-3p	neg	18829540	Bracken et al. (2008)

^apos: positive interaction, neg: negative interaction.