TABLE 3.

Univariate and multivariate Cox regression analyses of risk factors associated with overall survival.

HCC cohorts		Univariable analyses				Multivariable analyses
		p	HR	95.0% CI		p	HR	95.0% CI
Validation set	Age	0.418	1.012	0.984–1.041
	Gender	0.149	0.592	0.29–1.207
	T stage	0	4.017	1.925–8.38		0	8.257	2.168–31.451
	N stage	0.04	8.998	1.107–73.152		0.908	1.143	0.118–11.109
	M stage	0.088	3.602	0.825–15.724		0.259	4.284	0.343–53.561
	pTNM_stage	0	4.602	2.114–10.017		0.003	5.318	1.778–15.907
	grade	0.205	0.601	0.273–1.322
	recurrence	0.635	1.193	0.575–2.476
	Low risk group	0.001				0.019
	Mid risk group	0.005	3.936	1.515–10.224		0.033	5.677	1.151–27.994
	High risk group	0	8.064	2.687–24.201		0.005	11.994	2.119–67.908
Training set
	Age	0.399	1.007	0.991–1.023
	Gender	0.65	0.906	0.592–1.387
	T stage	0	2.428	1.595–3.697		0.028	1.968	1.078–3.594
	N stage	0.824	1.253	0.173–9.092		0.517	1.95	0.258–14.738
	M stage	0.012	13.563	1.763–104.315		0.003	26.515	2.979–236.021
	pTNM_stage	0	2.281	1.464–3.554		0	2.281	1.464–3.554
	grade	0.17	1.349	0.88–2.068
	recurrence	0.016	1.754	1.111–2.769		0.048	1.967	1.005–3.851
	Low risk group	0				0
	Mid risk group	0.009	1.842	1.169–2.905		0.084	1.854	0.92–3.734
	High risk group	0	4.85	2.702–8.706		0	5.262	2.311–11.981