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CAR-T cell control using a ribozyme switch responsive to (6R)-FA). Lack of ligand addition causes the formation of miRNA duplex from the pre miRNA. The miRNA prevents the ligand from binding to the receptor, leading to cell death. When (6R)-FA is added, it binds to the aptamer and prevents the formation of the miRNA duplex. This allows for cytokines to bind the receptor and form a dimer, which leads to cell proliferation. Created with Biorender.com.
