. 2021 Nov 17;4(6):1716–1727. doi: 10.1021/acsptsci.1c00188

Table 1. Examples of Aptamers That Bind to Immunomodulatory-Relevant Targets, Nucleic Acid Type, Binding Affinity (K_d), and References.

Target	Aptamer Type	K_d (nM)^a	Reference
4-1BB costimulatory receptor	RNA	40	(40)
OX40 cell surface receptor	RNA	8	(41)
cytotoxic T cell antigen-4	RNA	10	(42)
programmed cell death-1	DNA	112	(43)
tumor necrosis factor-α	DNA	7	(44)
interleukin-2 receptor-α	DNA	13.4	(45)
interleukin-6 receptor	DNA	0.2	(46)
interleukin-8	RNA	0.00172	(47)
interleukin-10 receptor	RNA	12	(48)
CD8⁺ T cell	DNA	18.3	(32)
CD8⁺ T cell	DNA	1.9	(32)
CD8⁺ T cell	DNA	2.4	(32)

Only targets with reported K_d values are indicated

Table 1. Examples of Aptamers That Bind to Immunomodulatory-Relevant Targets, Nucleic Acid Type, Binding Affinity (Kd), and References.