. 2021 Nov 17;4(6):1808–1817. doi: 10.1021/acsptsci.1c00199

Table 1. Human and Murine C5a Analogues Sequences and Synthesis Yields^a.

peptide	sequence^b	yield (%)
rhC5a	`NH`₂-MLQKKIEEIAAKYKHSVVKKCCYDGACVNNDETCEQRAARISLGPRCIKAFTECCVVASQLRANISHKDMQLGR-OH
[Nle⁷⁰]hC5a	`NH`₂-TLQKKIEEIAAKYKHSVVKKCCYDGACVNNDETCEQRAARISLGPRCIKAFTECCVVASQLRANISHKDXQLGR-OH	6.67
[Ser²⁷, Nle⁷⁰]hC5a	`NH`₂-TLQKKIEEIAAKYKHSVVKKCCYDGASVNNDETCEQRAARISLGPRCIKAFTECCVVASQLRANISHKDXQLGR-OH	10.11
[Ser²⁷, Nle⁷⁰]hC5a-desArg	`NH`₂-TLQKKIEEIAAKYKHSVVKKCCYDGASVNNDETCEQRAARISLGPRCIKAFTECCVVASQLRANISHKDXQLG-OH	6.74
Eu-DTPA-[Nle⁷⁰]hC5a	[Eu]Dtpa-TLQKKIEEIAAKYKHSVVKKCCYDGACVNNDETCEQRAARISLGPRCIKAFTECCVVASQLRANISHKDXQLGR-OH	0.20
Eu-DTPA-[Ser²⁷, Nle⁷⁰]hC5a	[Eu]Dtpa-TLQKKIEEIAAKYKHSVVKKCCYDGASVNNDETCEQRAARISLGPRCIKAFTECCVVASQLRANISHKDXQLGR-OH	0.88
mC5a	`NH`₂-NLHLLRQKIEEQAAKYKHSVPKKCCYDGARVNFYETCEERVARVTIGPLCIRAFNECCTIANKIRKESPHKPVQLGR-OH	0.54

Yield calculated from the final amount of pure peptide divided by maximum theoretical synthesis yield based on resin loading. Intramolecular disulfide-bonded cysteines are highlighted in bold. Position 27, which has a nonintramolecular bonded cysteine or a serine substitution, is underlined. Cys²⁷ is partially cysteinylated.

X denotes norleucine.

Table 1. Human and Murine C5a Analogues Sequences and Synthesis Yieldsa.

Table 1. Human and Murine C5a Analogues Sequences and Synthesis Yields^a.