Figure 8.

Treatment with lodoxamide can reverse pre-established lipid accumulation in hepatocytes. Hepatocytes from GPR35a-HA-expressing transgenic knock-in mice (scale bar = 100 μm) were maintained in culture and exposed to medium (vehicle only) or T0901317 (8 × 10^–6 M, 48 h) (T090). Lodoxamide (1 × 10^–5 M) (LOD) in (A), concentrations as indicated in (B), was then added with or without continued exposure to T0901317. (A) Representative visual images. Data quantified as relative lipid content (B), p < 0.05 a: versus vehicle, b: versus T0901317.