Table 3. Comparison of Ligands With Agonist Potency at Human and Mouse GPR35.
human GPR35a, pEC50 | mouse GPR35, pEC50 | ratio (log) (H/M) | |
---|---|---|---|
lodoxamide | 8.38 ± 0.02 | 5.72 ± 0.03 | 2.66 ± 0.05 |
bufrolin | 7.83 ± 0.02 | 6.81 ± 0.04 | 1.02 ± 0.06 |
zaprinast | 5.59 ± 0.01 | 6.18 ± 0.01 | –0.59 ± 0.0 |