Table 4. Structure–Activity Relationships of the 2-Sulfonylpyrimidine/2-Thiopyrimidine Derivatives.

Chembridge ID#	Cpd	R1	R2	R3	R4	R5	R6	IC50 (μM) [95% CI]
9007737	C9	Me	H	I	H	H	H	118 [92–162]
9002388	C9.1	Me	H	H	H	H	H	300 [204–543]
7992875	C9.2	Me	Me	H	H	H	H	81 [58–1009]
7993471	C9.3	Me	Cl	H	H	H	H	53 [45–63]
7997746	C9.4	Me	H	Me	H	H	H	78 [64–99]
9000796	C9.5	Me	H	Cl	H	H	H	45 [37–55]
9331527	C9.6	Me	H	CF3	H	H	H	67 [52–91]
9002023	C9.7	Me	H	H	OCHF2	H	H	34 [28–42]
7999377	C9.8	Me	H	H	OMe	H	H	54 [45–66]
7998346	C9.9	Me	Me	H	H	Me	H	102 [89–119]
7994681	C9.10	Me	H	Me	Me	H	H	70 [67–99]
9001867	C9.11	Me	Me	H	H	H	Me	186 [149–164]
7992530	C9.12	Me	Cl	H	Cl	H	H	19 [14–24]
9002556	C9.13	Me	2-naphthyl					37 [22–34]
7995713	C9.14	Et	H	H	H	H	H	133 [1122–147]
9001771	C9.15	Et	F	H	H	H	H	65 [54−83]
9008307	C9.16	Et	H	Me	H	H	H	79 [67−96]
9005591	C9.17	Et	H	Cl	H	H	H	35 [28−43]
9004507	C9.18	Et	H	H	Me	H	H	36 [28−46]
7997031	C9.19	Et	H	H	Et	H	H	24 [21−29]
7997789	C9.20	Et	H	H	I	H	H	23 [12−41]
7994081	C9.21	Pr	H	Me	H	H	H	59 [50−71]
9005204	C9.22	Pr	H	Cl	H	H	H	20 [17−24]
7987235	C9.23	Me	H	I	H	H	H	40 [25−47]
9033235	C9.24	Me	H	Me	H	Me	H	36 [21−56]
9007737	C9.25	Et	H	NO2	H	H	H	29 [26−33]