Table 5. GAC versus GLS2 Selectivity of the Best 2-Sulfonylpyrimidine/2-Thiopyrimidine Derivatives.

	IC50 (μM) [95% CI]
cpd	GAC	GLS2	enzymatic selectivity ratio (IC50 GLS2/IC50 GAC)
C9	118 [92–162]	>200	>1.7
C9.12	19 [14–24]	>200	>10.5
C9.19	24 [21–29]	>200	>8.3
C9.20	23 [12–41]	>200	>8.7
C9.22	20 [17–24]	>200	>10
C9.24	36 [21–56]	>200	>5.5
C9.25	29 [26–33]	106 [45–892]	3.7
CB-839	0.034 [0.030–0.039]	>200	>5882