Table 6. MDA-MB-231 versus SKBR3 Selectivity of the Best 2-Sulfonylpyrimidine/2-Thiopyrimidine Derivatives.

	IC50 (μM) [95% CI]
cpd	MDA-MB-231	SKBR3	cell selectivity ratio (IC50 SKBR3/IC50 MDA-MB-231)
C9	48 [43–53]	∼69	∼1.4
C9.12	17 [15–19]	23 [22–26]	1.4
C9.19	6 [6–7]	∼13	∼2.2
C9.20	∼28	∼29	∼1.0
C9.22	4.2 [4.0–4.4]	∼13	∼3.1
C9.24	105 [73–172]	>200	>1.9
C9.25	180 [73–??]	>400	>2.2
CB-839	0.038 [0.031–0.048]	>1	>26