Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Nov 30;12:779547. doi: 10.3389/fphys.2021.779547

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2021 You and Chen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Effects of aging on denervation-induced muscle atrophy. Mice at 8months (8M) and 27months (27M) of age were subjected to denervation (right leg, DNV or D) and sham (contralateral left leg, CTL or C) surgeries, and tibialis anterior (TA), gastrocnemius (GAST), extensor digitorum longus (EDL), and soleus (SOL) muscles were collected 7days after surgeries. (A–D) Muscle weight and total protein content in TA (A), GAST (B), EDL (C), and SOL (D). (E,F) mRNA levels of denervation markers in TA (E) and GAST (F). n=5–3 mice/group. Data are presented as mean±SEM. and SD (whisker, upper panels in A–D) and expressed relative to 8M/CTL except for upper panels in (A–D). ^*p<0.05, ^**p<0.01, and ^***p<0.001 vs. CTL by two-way mixed ANOVA. ^#p<0.05, ^##p<0.01, and ^###p<0.001 vs. 8M within the same surgery groups by two-way mixed ANOVA. Inter, interaction between surgery effects (Surg) and age effects by two-way mixed ANOVA.