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. 2021 Nov 30;12:779547. doi: 10.3389/fphys.2021.779547

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Copyright © 2021 You and Chen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effects of aging on ribosomal biogenesis during muscle denervation. Mice at 8months (8M) and 27months (27M) of age were subjected to denervation (right leg, DNV) and sham (contralateral left leg, CTL) surgeries, and TA and GAST muscles were collected 7days post-surgeries. (A,B) Quantification of total RNA (A) and 28S+18S rRNA (B) per mg muscle in TA. (C,D) Quantification of total RNA (C) and 28S+18S rRNA (D) per mg muscle in GAST. n=4–3 mice/group. Data are presented as mean±SEM. and expressed relative to 8M/CTL or as % of CTL (right panels). ^***p<0.05 vs. CTL by two-way mixed ANOVA. ^#p<0.05 vs. 8M within the same surgery groups by two-way mixed ANOVA. ^††p<0.01 and ^†††p<0.001 by unpaired t test. Inter, interaction between surgery effects (Surg) and age effects by two-way mixed ANOVA.