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. 2021 Nov 30;13:772980. doi: 10.3389/fnagi.2021.772980

FIGURE 3.

FIGURE 3

Open field test performance for 4-, 6-, and 8-month-old WT and APP/PS1 mice (n = 8–9/group). (A–C) In 4-month-old WT and APP/PS1 mice, no statistically significant differences were observed in the indicators (total distance, time spent in the center, and immobile time) of OFT. (D–F) In 6-month-old mice, APP/PS1 mice showed reduced total distance (*p < 0.05, unpaired t-test) and increased immobile time (**p < 0.001, unpaired t-test) in OFT, compared with WT mice, but there was no difference in the time spent in the center. (G–I) In 8-month-old mice, there were no differences in these indicators of OFT. (J–L) There was no significant correlation between the total distance in OFTs and the performance in Y-maze, NOR, or Barnes maze in 6-month-old APP/PS1 mice. Each point on these graphs represents an independent mouse.