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. 2021 Nov 30;13:772980. doi: 10.3389/fnagi.2021.772980

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Copyright © 2021 Xu, Zhou, Hu, Jiang, Dong, Shen, Lou, Yang, Ji, Ruan and Zhang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The expression of synapse-associated proteins and glutamate receptor subunit proteins in the CA1 area of 8-month-old WT and APP/PS1 mice. (A) Representative western blots of glutamate receptor subunits. (B–D) Quantitative of NMDAR subunits expression showed a significant decrease of NR2A and NR2B expression (n = 6 mice/group, *p < 0.05, **p < 0.01, unpaired t-test) in the hippocampus in 8-month-old APP/PS1 mice compared with WT mice, but there was no difference on the expression of NR1 from two groups. (E,F) Quantitative of AMPA receptors subunits (GluR1, GluR2) expression showed no change in hippocampus from 8-month-old APP/PS1 mice and WT mice. (G) Representative western blots of PSD95 and SNAP25. (H,I) A significant decrease of the levels of PSD95 and SNAP25 in the hippocampus from 8-month-old APP/PS1 mice compared with WT mice (n = 4 mice/group, *p < 0.05, unpaired t-test).