Source	Search strategy	Hits retrieved
VASCULAR REGISTER IN CRSW	#1 Knee* AND INREGISTER #2 above‐knee AND INREGISTER #3 Through‐knee AND INREGISTER #4 #1 OR #2 OR #3 #5 Amput* AND INREGISTER #6 stump* AND INREGISTER #7 #5 OR #6 #8 #4 AND #7	Feb 2021: 116
CENTRAL via CRSW	#1 MESH DESCRIPTOR Knee EXPLODE ALL WITH QUALIFIER SU AND CENTRAL:TARGET #2 MESH DESCRIPTOR Knee Joint EXPLODE ALL WITH QUALIFIER SU AND CENTRAL:TARGET #3 Knee* AND CENTRAL:TARGET #4 "above‐knee" AND CENTRAL:TARGET #5 "Through‐knee" AND CENTRAL:TARGET #6 "trans femoral" AND CENTRAL:TARGET #7 #1 OR #2 OR #3 OR #4 OR #5 OR #6 #8 MESH DESCRIPTOR Amputation EXPLODE ALL AND CENTRAL:TARGET #9 MESH DESCRIPTOR Amputation Stumps EXPLODE ALL AND CENTRAL:TARGET #10 MESH DESCRIPTOR Amputees EXPLODE ALL AND CENTRAL:TARGET #11 "residua* limb*" AND CENTRAL:TARGET #12 (phantom adj6 limb*) AND CENTRAL:TARGET #13 amput* AND CENTRAL:TARGET #14 disarticulat* AND CENTRAL:TARGET #15 exarticulat* AND CENTRAL:TARGET #16 postamputation* AND CENTRAL:TARGET #17 post‐amputation* AND CENTRAL:TARGET #18 stump* AND CENTRAL:TARGET #19 Gritti‐Stokes AND CENTRAL:TARGET #20 Mazet AND CENTRAL:TARGET #21 Burgess AND CENTRAL:TARGET #22 #8 OR #9 OR #10 OR #11 OR #12 OR #13 OR #14 OR #15 OR #16 OR #17 OR #18 OR #19 OR #20 OR #21 #23 #7 AND #22	Feb 2021: 509
Clinicaltrials.gov	Amputation OR amputate OR amputee OR stump | Knee OR above‐knee OR Through‐knee	Feb 2021: 142
ICTRP search portal	Amputation OR amputate OR amputee OR stump | Knee OR above‐knee OR Through‐knee	Feb 2021: 0
MEDLINE (Ovid MEDLINE Epub Ahead of Print, In‐Process & Other Non‐Indexed Citations; Ovid MEDLINE Daily; and Ovid MEDLINE) 1946 to present	1 exp Knee/su [Surgery] 2 exp Knee Joint/su [Surgery] 3 Knee*.ti,ab. 4 "above‐knee".ti,ab. 5 "Through‐knee".ti,ab. 6 "trans femoral".ti,ab. 7 or/1‐6 8 exp Amputation/ 9 exp Amputation Stumps/ 10 exp Amputees/ 11 "residua* limb*".ti,ab. 12 (phantom adj6 limb*).ti,ab. 13 amput*.ti,ab. 14 disarticulat*.ti,ab. 15 exarticulat*.ti,ab. 16 postamputation*.ti,ab. 17 post‐amputation*.ti,ab. 18 stump*.ti,ab. 19 Gritti‐Stokes.ti,ab. 20 Mazet.ti,ab. 21 Burgess.ti,ab. 22 or/8‐21 23 7 and 22 24 randomized controlled trial.pt. 25 controlled clinical trial.pt. 26 randomized.ab. 27 placebo.ab. 28 drug therapy.fs. 29 randomly.ab. 30 trial.ab. 31 groups.ab. 32 or/24‐31 33 exp animals/ not humans.sh. 34 32 not 33 35 23 and 34	Feb 2021: 942
Embase	1 exp knee/su [Surgery] 2 exp knee/su [Surgery] 3 Knee*.ti,ab. 4 "above‐knee".ti,ab. 5 "Through‐knee".ti,ab. 6 "trans femoral".ti,ab. 7 or/1‐6 8 exp amputation/ 9 exp amputation stump/ 10 exp amputee/ 11 "residua* limb*".ti,ab. 12 (phantom adj6 limb*).ti,ab. 13 amput*.ti,ab. 14 disarticulat*.ti,ab. 15 exarticulat*.ti,ab. 16 postamputation*.ti,ab. 17 post‐amputation*.ti,ab. 18 stump*.ti,ab. 19 Gritti‐Stokes.ti,ab. 20 Mazet.ti,ab. 21 Burgess.ti,ab. 22 or/8‐21 23 7 and 22 24 randomized controlled trial/ 25 controlled clinical trial/ 26 random$.ti,ab. 27 randomization/ 28 intermethod comparison/ 29 placebo.ti,ab. 30 (compare or compared or comparison).ti. 31 ((evaluated or evaluate or evaluating or assessed or assess) and (compare or compared or comparing or comparison)).ab. 32 (open adj label).ti,ab. 33 ((double or single or doubly or singly) adj (blind or blinded or blindly)).ti,ab. 34 double blind procedure/ 35 parallel group$1.ti,ab. 36 (crossover or cross over).ti,ab. 37 ((assign$ or match or matched or allocation) adj5 (alternate or group$1 or intervention$1 or patient$1 or subject$1 or participant$1)).ti,ab. 38 (assigned or allocated).ti,ab. 39 (controlled adj7 (study or design or trial)).ti,ab. 40 (volunteer or volunteers).ti,ab. 41 trial.ti. 42 or/24‐41 43 23 and 42	Feb 2021: 1377
CINAHL	S38 MH "Random Assignment"  S37 S22 AND S36  S36 S23 OR S24 OR S25 OR S26 OR S27 OR S28 OR S29 OR S30 OR S31 OR S32 OR S33 OR S34 OR S35  S35 MH "Random Assignment"  S34 MH "Triple‐Blind Studies"  S33 MH "Double‐Blind Studies"  S32 MH "Single‐Blind Studies"  S31 MH "Crossover Design"  S30 MH "Factorial Design"  S29 MH "Placebos"  S28 MH "Clinical Trials"  S27 TX "multi‐centre study" OR "multi‐center study" OR "multicentre study" OR "multicenter study" OR "multi‐site study"  S26 TX crossover OR "cross‐over"  S25 AB placebo*  S24 TX random*  S23 TX "latin square"  S22 S6 AND S21  S21 S7 OR S8 OR S9 OR S10 OR S11 OR S12 OR S13 OR S14 OR S15 OR S16 OR S17 OR S18 OR S19 OR S20  S20 TX Burgess  S19 TX Mazet  S18 TX Gritti‐Stokes  S17 TX stump*  S16 TX post‐amputation*  S15 TX postamputation*  S14 TX exarticulat*  S13 TX disarticulat*  S12 TX amput*  S11 TX phantom N6 limb*  S10 TX "residua* limb*"  S9 (MH "Amputees")  S8 (MH "Amputation Stumps")  S7 (MH "Amputation+")  S6 S1 OR S2 OR S3 OR S4 OR S5  S5 TX "trans femoral"  S4 TX "Through‐knee"  S3 TX "above‐knee"  S2 TX Knee*  S1 (MH "Knee Joint+/SU")	Feb 2021: 407
TOTAL before de‐duplication		3493
TOTAL after de‐duplication		2520